Remove the screw 2 from within the opening where the manual door lock lever resides.
How to take door panel off 07 chevy 250.
When you remove the phillips screw from interior handle plastic bezel you have to then pull off that bezel and remove one more phillips behind it.
This can include courtesy lights that are pried off and disconnected and heated seat switches you must pry off with the trim stick.
Using a suitable flat bladed tool gently pry the manual lock lever from the door trim panel.
Pull the door upward and outward to disconnect it from its clips on the door and unplug any wiring harnesses behind it.
Remove the side view mirror sail located in the upper corner of the door panel.
Once the two retaining caps are released pivot the top of the sail out and extract it from the bottom anchor on the door frame.
Remove the push in fastener 3 at the front edge of the door trim.
Pry it off with the small angled trim tool from the top and rear side.
I wish i was able to find pictures or a video to change out my speakers.
Remove the cap 5 covering the screw on the rear edge of the trim panel.
Remove the trim panel screws.
To remove the door panel on a chevrolet truck you need to unplug all of the electrical connectors and remove a few trim pieces.
Disconnect any optional lights and switches in the door.
So here is a quick slideshow i made for anyone who might be doing the same thing.
This trim piece covers the interior side of the side view mirror.